Skin aging is currently a very interesting topic. This ongoing process is universal and irreversible and is characterized by the appearance of morphological and physiological changes that occur in humans over time, leading to decreased activity of various organs and tissues. proteoglycans benefits for skin have hit the scene with powerful effects that are revolutionizing people who are rethinking anti-aging results. Combined with glycosaminoglycans they boost the production of hyaluronic acid and give the skin more moisture. Dermabiotecnica Serum multivit with vitamin C,E,F and Dermabiotecnica Gold multyvit Serum, along with Vitamin C, Vitamin E, and Proteoglycans, helps combat the effects of free radicals and promotes the synthesis of new collagen.
In fact, along with collagen, elastin and hyaluronic acid, proteoglycans are the major extracellular structural components of skin. Although we often associate skin aging problems with a lack of collagen, we are unaware of the fundamental role of proteoglycans in the dermal matrix.Over the years, the skin loses this structure and the body loses It ceases to produce it naturally.For this reason, topical application of proteoglycans can help counteract and naturally delay premature skin aging.
What are Proteoglycans?
Proteoglycans are protein-bound polysaccharides (GAGs). They reside in the spaces between cells, a physiological component known as the extracellular matrix or ECM. The extracellular matrix is like glue in that it holds cells together and keeps them mobile as a group.The ECM also helps protect them from external forces and chemicals that tear them apart. . The three-dimensional structure of proteoglycans is like a sponge.
They take up a lot of space but are not dense and of course love water. Proteoglycans in skincare routine creams are ideal for dehydrated skin as they provide a very quick hydration and lifting effect thanks to the accumulation of moisture. Whether you want to fight fatigue, stress or the first signs of aging, this could be your beauty product. , helps slow down the aging of the skin.It also has firming properties and improves the epidermal structure and elasticity of the skin.
Structure of proteoglycans
carbohydrates
Proteoglycans function as polysaccharides rather than proteins because 95% by weight are composed of glycosaminoglycans. Glycosaminoglycan chains are composed of alternating hexosamine and hexuronic acid or galactose units. There is also a glycopeptide binding region that connects the polysaccharide chain to the core protein containing N-linked and/or O-linked oligosaccharides.
The regular polymeric arrangement of glycosaminoglycans is the result of repeating units in the glycosaminoglycan chain. However, examination of the glycosaminoglycan chains revealed clear heterogeneity in the individual polysaccharide units.
core protein
Proteoglycans can be classified based on their core protein. For example, one family consists of large extracellular chondroitin sulfate proteoglycans that can interact specifically with hyaluronic acid. Several proteoglycans of the extracellular matrix and proteoglycans present in various connective tissues belong to this category.
Another family of proteoglycans consists of small homologous core proteins containing one or two glycosaminoglycan chains. These small core proteins include decorin, biglycan, fibromodulin, and others. Heparan sulfate proteoglycans are related to heparan sulfate proteoglycans that are present extracellularly or in the basement membrane and secreted by the Engelbreth-Holm-Swarm (EHS) tumor cell line.
Proteoglycans benefits for skin
The most common proteoglycans in human skin are decorin, perlecan, and versican. Of particular note is that decorin interacts with collagen and versican is present in the elastic fibers of the skin.Both proteoglycans play a major role in the changes that occur in the properties of human skin over time. .
Decorin
It is a small leucine-rich proteoglycan with glycosaminoglycan chains of the chondroitin sulfate (CS) or dermatan sulfate (DS) type. It regulates a variety of cellular processes including collagen fibril formation, wound healing, angiogenesis, tumor growth and autophagy. These functions arise from a range of decorin/protein interactions, including interactions with single side chains of glycosaminoglycans. There are two main features to notice.
Maintenance of cell structure and external signaling, leading to anti-tumor effects.
What are the proteoglycans benefits for skin?
Most of the changes that occur in the skin over time occur in the dermis layer where changes in collagen and proteoglycans occur.
Proteoglycan structures are involved in multiple functions performed in the skin, such as preventing wrinkle formation, increasing skin hydration and elasticity, having antioxidant effects, and protecting against oxidative stress caused by increased free radicals.
During aging, the endogenous proteoglycans of the extracellular matrix decrease in size and the skin becomes more fragile. Therefore, the exogenous contribution of this molecule can slow or prevent aging and help hydrate and repair skin tissue.
- It has antioxidant properties and has a soothing effect on the skin
- Ideal for dry skin and skin exposed to UVA rays.
- They deeply moisturize the skin.
- They act in the extracellular matrix, occupy the spaces that exist between cells, and supply the ECM with nutrients.
- Good levels of proteoglycans are important for keeping your skin smooth and preventing aging.
- providing a restorative effect and an anti-wrinkle effect.
- stimulating collagen synthesis.
Why are proteoglycans rare?
The benefits of proteoglycans were first discovered in his 1970s, but their spectacular benefits and complexity of extraction have made them very expensive cosmetic ingredients. Valued at $300,000 per gram, it was considered more valuable than diamonds. Forty years later, researchers at Hirosaki University in Aomori Prefecture, Japan, discovered a way to extract proteoglycans from the nasal cartilage of salmon. That moment of inspiration was the breakthrough.
Where are proteoglycans benefits for skin located?
Proteoglycans are found primarily in the extracellular matrix (ECM) of nearly all human tissues, including lung and cornea. They are particularly useful in joints and cartilage. Proteoglycans are localized intracellularly, on the surface of the cell membrane, or at the cell membrane.
